RAF Typhoon FGR4s have conducted a mission with French warplanes in a combined operation on an underground arms cache in Syrian territory employed by the IS group, per a report from the UK's MoD.
The location, identified by intelligence, was assessed as housing weapons and explosive materials, the statement said, and was located in hills just north of the ancient city of Palmyra in central Syria.
"Our fighter planes utilized precision-guided Paveway IV munitions to target a several entry passages down to the depot... early reports indicate the strike was effective," the MoD said.
There was no evidence of any harm to civilians in the attack on Saturday evening and every plane involved made a safe return, the ministry further stated.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as ISIS - enforced extremist governance over parts of Syria and Iraq prior to its 2019 collapse.
"This strike shows the UK's leading role, and determination to operate in unison with allied nations, to stamp out any resurgence of IS and their violent and radical beliefs in the Middle East," Britain's Defence Chief the Defence Secretary remarked.
British military aircraft have conducted surveillance missions over Syria to "forestall any attempted comeback" of IS subsequent to its routing at the battle of Baghuz in 2019, the MoD reported.
"I want to thank all the members of the UK armed forces who took part in this strike for their skill and their bravery," the Defence Secretary said. "They were part of thousands of British personnel stationed over Christmas and New Year. This mission, to remove terrorist threats who threaten our security, demonstrates how our armed forces are always on standby, all year round, keeping Britain secure at home and influential overseas."
During December, the American forces executed what it termed a "major assault" targeting Daesh sites in Syria, subsequent to an attack killed two US servicemembers and a local interpreter in Palmyra.
The United Nations estimates Islamic State still boasts between 5,000 and 7,000 fighters in both countries.